产品货号 :  mlR18447

英文名称 :  LUZP4/CT28

中文名称 :  亮氨酸拉链蛋白4抗体

别    名 :  Cancer/testis antigen 28; CT 8; CT-28; CT28; ENSMUSG00000072927; HOM TES 85; HOM TES 85 tumor antigen; Leucine zipper protein 4; LUZP4; LUZP4_HUMAN; OTTHUMP00000023875; RP1-237H22.1; RP23-463M4.2; Tumor antigen HOM-TES-85.  

研究领域 :  肿瘤  细胞生物  免疫学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  36kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human LUZP4/CT28:31-130/313

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].]

Function:

Export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Binds NXF1, enhances its RNA-binding activity and is required for its localization to the nuclear rim. Associates with the TREX complex via its interaction with the TREX components THOC1, THOC5 and DDX39B/UAP56. Capable of complementing knockdown of ALYREF/THOC4 and partially complementing a double ALYREF/UIF knockdown in vivo. Required for the growth of the melanoma cell line MeWo (PubMed:25662211).

Subunit:

Interacts NXF1, NXF2, THOC1, THOC5, DDX39B/UAP56 and SRRT.

Subcellular Location:

Nucleus. Cytoplasm. Note=In nuclear speckles. Relocalizes to the cytoplasm during cell division.

Tissue Specificity:

Expressed specifically in testis. Also expressed in a wide variety of cancer types, but particularly high levels of expression observed in melanoma cells.

SWISS:

Q9P127

Gene ID:

51213

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.