产品货号 :  mlR16818

英文名称 :  KRT23

中文名称 :  细胞角蛋白23抗体

别    名 :  CK 23; CK-23; CK23; Cytokeratin 23; Cytokeratin-23; Cytokeratin23; DKFZP434G032; HAIK 1; HAIK1; Histone deacetylase inducible keratin 23; Hyperacetylation inducible type I keratin; K1C23_HUMAN; K23; Keratin 23 (histone deacetylase inducible); Keratin 23; Keratin; Keratin type I cytoskeletal 23; Keratin-23; Keratin23; KRT 23; KRT23; MGC26158; type I cytoskeletal 23; Type I intermediate filament cytokeratin.  

研究领域 :  细胞生物  信号转导   

抗体来源 :  Rabbit

克隆类型 :  Polyclonal 

交叉反应 :   Human, 

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 :  48kDa

细胞定位 :  细胞浆 

性    状 :  Lyophilized or Liquid 

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human KRT23:26-120/462 <Extracellular> 

亚    型 :  IgG 

纯化方法 :  affinity purified by Protein A 

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

PubMed :  PubMed 

产品介绍background:

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] 

Function:

Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).

Subunit:

Interacts with ERLEC1 (By similarity). 

Subcellular Location:

Membrane; Single-pass type I membrane protein (Potential).

Similarity:

Contains 1 CUB domain.

Contains 1 kringle domain.

Contains 1 WSC domain. 

SWISS:

Q9C075 

Gene ID:

25984 

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.