产品货号 :  mlR16830

英文名称 :  KRT71

中文名称 :  细胞角蛋白71抗体 

别    名 :  CK-71; Cytokeratin-71; hK6irs; hK6irs1; K2C71_HUMAN; K6IRS1; K71; Keratin 6 irs; Keratin; keratin, type II cytoskeletal 71; Keratin-71; KRT6IRS; KRT6IRS1; KRT71; MGC119390; MGC119391; OTTHUMP00000236990; type II cytoskeletal 71; Type II inner root sheath-specific keratin-K6irs1; Type-II keratin Kb34.   

研究领域 :  细胞生物  信号转导  

抗体来源 :  Rabbit 

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 :  57kDa 

细胞定位 :  细胞浆 

性    状 :  Lyophilized or Liquid 

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human KRT71:451-523/523 

亚    型 :  IgG 

纯化方法 :  affinity purified by Protein A 

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed 

产品介绍background:

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

Function:

Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. 

Subunit:

Heterodimer of a type I and a type II keratin. Associates with KRT16 and/or KRT17 (By similarity). 

Tissue Specificity:

Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level).

DISEASE:

Hypotrichosis 13 (HYPT13) [MIM:615896]: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and bodyhair involvement can be very variable, within as well as between families. HYPT13 is characterized by sparse woolly hair.

Similarity:

Belongs to the intermediate filament family. 

SWISS:

Q3SY84

Gene ID:

112802 

Important Note:

This product as supplie