产品货号 :  mlR12697

英文名称 :  PLA2G1B

中文名称 :  分泌型磷脂酶A2抗体

别    名 :  Group IB phospholipase A2; Group IB secretory phospholipase A2; MGC119834; MGC119835; PA21B_HUMAN; Phosphatidylcholine 2 acylhydrolase; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; Phospholipase A2 group IB (pancreas); Phospholipase A2 group IB; PLA 2; PLA2; PLA2A; PLA2G1B; PPLA 2; PPLA2; sPLA2IB.  

研究领域 :  肿瘤  细胞生物  信号转导  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  14kDa

细胞定位 :  分泌型蛋白

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PLA2G1B:81-148/148

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

Function:

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Subunit:

Monomer or homodimer (By similarity). The inactive pro-form is a homotrimer.

Subcellular Location:

Secreted.

Post-translational modifications:

Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.

Similarity:

Belongs to the phospholipase A2 family.

SWISS:

P04054

Gene ID:

5319

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.