产品货号 : mlR11890
英文名称 : Monoamine oxidase A+B
中文名称 : 单氨氧化酶A+B抗体
别 名 : Adrenalin oxidase; AOFA_HUMAN; AOFB_HUMAN; Amine oxidase (flavin containing) A; Amine oxidase (flavin containing); Amine oxidase (flavin containing) B; Brunner syndrome; MAO A; MAO; MAO brain; MAO platelet; MAOA; MAOB; Monoamine oxidase A; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase type A; Monoamine oxidase type B; Tyramine oxidase.
研究领域 : 细胞生物 神经生物学 信号转导
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 60+59kDa
细胞定位 : 细胞浆 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human Monoamine oxidase A+B:131-230/527
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Monoamine oxidase A and B catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. MAOB preferentially degrades benzylamine and phenylethylamine
Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Subunit:
Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.
Subcellular Location:
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Tissue Specificity:
Heart, liver, duodenum, blood vessels and kidney.
DISEASE:
Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.
Similarity:
Belongs to the flavin monoamine oxidase family.
SWISS:
P21397 P27338
Gene ID:
4128 4129
Database links:
UniProtKB/Swiss-Prot: P21397.1 UniProtKB/Swiss-Prot: P27338.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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