产品货号 : mlR20099
英文名称 : ARL8B
中文名称 : ADP核糖基化样因子8B抗体
别 名 : ADP ribosylation factor like 10C; ADP-ribosylation factor-like protein 10C; ADP-ribosylation factor-like protein 8B; ARL10C; ARL8B; ARL8B_HUMAN; FLJ10702; Gie1; Novel small G protein indispensable for equal chromosome segregation 1.
研究领域 : 细胞生物 细胞周期蛋白 细胞分化 表观遗传学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Cow, Rabbit,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 22kDa
细胞定位 : 细胞浆 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human ARL8B:1-100/186
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : ADP-ribosylation factors (ARFs) are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of Cholera Toxin. ARF’s are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL8B (ADP-ribosylation factor-like protein 8B), also known as ARL10C or GIE1, is a 186 amino acid protein that localizes to the late endosome membrane and belongs to the ARL family of ARF-like GTPase proteins. Expressed ubiquitously, ARL8A interacts with Tubulin and is thought to play a role in lysosome motility, as well as in chromosomal segregation. The gene encoding ARL8B maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.
Function:
May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635).
Subunit:
Interacts with tubulin.
Subcellular Location:
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the small GTPase superfamily. Arf family.
SWISS:
Q9NVJ2
Gene ID:
55207
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.