产品货号 :  mlR10701

英文名称 :  HS6ST1

中文名称 :  硫酸乙酰肝素6脑苷脂转硫酸酶1抗体

别    名 :  6OST 1; 6OST1; DKFZp547H098; FLJ25392; H6 ST1; H6ST 1; H6ST1_HUMAN; Heparan sulfate 6 O sulfotransferase 1; Heparan sulfate 6 sulfotransferase; Heparan sulphate 6 O sulphotransferase 1; Heparan-sulfate 6-O-sulfotransferase 1; HS6 ST1; HS6ST 1; HS6ST ; HS6ST-1; HS6ST1; MGC116899; MGC116901.  

研究领域 :  细胞生物  神经生物学  信号转导  生长因子和激素  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Horse, Rabbit,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  48kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human HS6ST1:311-411/411

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  Heparan sulfate structures, which are responsible for executing multiple biologic activities, are generated and regulated by heparan sulfate (HS) biosynthetic enzymes. HS6ST1 (heparan sulfate 6-O-sulfotransferase 1), also known as HS6ST, is a 411 amino acid single-pass type II membrane protein that exists as multiple alternatively spliced isoforms and belongs to the sulfotransferase 6 family. Expressed in fetal brain, HS6ST1 functions as a 6-O-sulfation enzyme that specifically catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the N-sulfoglucosamine residue (GlcNS) HS. HS6ST1 is subject to post-translational N-glycosylation and is encoded by a functional gene on human chromosome 2 and a pseudogene on human chromosome 1 (known as LOC728969).

Function:

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Subcellular Location:

Membrane; Single-pass type II membrane protein

Tissue Specificity:

Expressed in fetal brain.

Post-translational modifications:

N-glycosylated.

Similarity:

Belongs to the sulfotransferase 6 family.

SWISS:

O60243

Gene ID:

9394

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.