产品货号 : mlR9202
英文名称 : IGSF12
中文名称 : 免疫球蛋白超家族成员12抗体
别 名 : IGSF12; CD300 antigen-like family member A; CD300a; CD300a molecule; CLM-8; CLM8_HUMAN; CMRF 35 H9; CMRF-35-H9; CMRF35-H; CMRF35-H9; CMRF35-like molecule 8; CMRF35H leukocyte immunoglobulin like receptor; CMRF35H9; IgSF12; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; IRC1; IRC1/IRC2; IRC2; IRp60; Leukocyte membrane antigen; Mast cell derived paired immunoglobulin like receptor 1; NK inhibitory receptor; Polymeric immunoglobulin receptor 4.
研究领域 : 免疫学 细胞类型标志物
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 31kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human IGSF12/CD300:41-140/299 <Extracellular>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMe : dPubMed
产品介绍 : Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.
Function:
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.
Subunit:
Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential).
Tissue Specificity:
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
Post-translational modifications:
Phosphorylated on tyrosine.
Similarity:
Belongs to the CD300 family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q9UGN4
Gene ID:
11314
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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