产品货号 :  mlR18985

英文名称 :  N4BP2

中文名称 :  E3泛素连接酶NEDD4结合蛋白2抗体

别    名 :  B3BP; BCL 3 binding protein; BCL3 binding protein; FLJ10680; KIAA1413; Nedd4 binding protein 2.  

研究领域 :  细胞生物  免疫学  神经生物学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  199kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human N4BP2:281-380/1770

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. [provided by RefSeq, Jul 2008]

Function:

Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.

Subunit:

Binds NEDD4 By similarity. Binds BCL3 and CREBBP.

Subcellular Location:

Cytoplasm

Post-translational modifications:

Ubiquitinated; this targets the protein for degradation by the proteasome

Similarity:

Contains 1 CUE domain.

Contains 1 Smr domain.

SWISS:

Q86UW6

Gene ID:

55728

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.