产品货号 :  mlR19942

英文名称 :  TM2D1

中文名称 :  β淀粉样蛋白结合蛋白抗体

别    名 :  BBP; Beta amyloid binding protein; hBBP; TM2 domain containing 1; TM2 domain containing protein 1; TM2D1.  

研究领域 :  细胞生物  神经生物学  信号转导  细胞凋亡  Alzheimer's  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  19kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human TM2D1:38-100/207

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. [provided by RefSeq, Dec 2008]

Function:

May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42.

Subunit:

Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP.

Subcellular Location:

Membrane; Multi-pass membrane protein.

Tissue Specificity:

Widely expressed.

Post-translational modifications:

N-glycosylated.

Similarity:

Belongs to the TM2 family.

SWISS:

Q9BX74

Gene ID:

83941

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.