产品货号 :  mlR17813 

英文名称 :  MRPS16 

中文名称 :  线粒体核糖体蛋白S16抗体 

别    名 :  28S ribosomal protein S16; 28S ribosomal protein S16 mitochondrial; CGI-132; COXPD2; mitochondrial; Mitochondrial ribosomal protein S16; MRP-S16; mrps16; RPMS16; RT16_HUMAN; S16mt.   

研究领域 :  细胞生物  转录调节因子  线粒体  表观遗传学   

抗体来源 :  Rabbit

克隆类型 :  Polyclonal 

交叉反应 :  Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, 

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 :  12kDa 

细胞定位 :  细胞核 线粒体 

性    状 :  Lyophilized or Liquid 

浓    度 :  1mg/ml 

免 疫 原 :  KLH conjugated synthetic peptide derived from human MRPS16:35-100/137 

亚    型 :  IgG 

纯化方法 :  affinity purified by Protein A 

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed 

产品介绍 :  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008] 

Subcellular Location:

Mitochondrion. 

Tissue Specificity:

Defects in MRPS16 are the cause of combined oxidative phosphorylation deficiency type 2 (COXPD2) [MIM:610498]. Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD2 symptoms include fatal neonatal metabolic acidosis with agenesisof the corpus callosum.

Similarity:

Belongs to the ribosomal protein S16P family. 

SWISS:

Q9Y3D3

Gene ID:

51021

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.