产品货号 : mlR20077
英文名称 : Endokinin-C
中文名称 : Endokinin-C抗体
别 名 : EK; Endokinin; HK 1; HK1; TKN4_HUMAN; Preprotachykinin C; TAC4; Tachykinin 4 (hemokinin); Tachykinin 4; Endokinin C.
研究领域 : 细胞生物 免疫学 神经生物学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 1.5kDa
细胞定位 : 分泌型蛋白
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human Endokinin-C:41-113/113
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Hemokinin 1 are from the Tachykinins family of proteins that are active peptides which excite neurons. They evoke behavioral responses and are potent vasodilators and secretagogues. Hemokinin 1 involved in contraction (directly or indirectly) of many smooth muscles. Hemokinin 1is cleaved in to three short peptides Edokinin A,B,C. Endokinin A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with Endokinin C. Endokinin A/B reduces arterial blood pressure and increases sperm motility.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.
Similarity:
Belongs to the tachykinin family.
SWISS:
Q86UU9
Gene ID:
255061
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
