产品货号 :  mlR17099

英文名称 :  Lano/LRRC1

中文名称 :  富含亮氨酸重复序列蛋白1抗体

别    名 :  dJ523E19.1; FLJ10775; FLJ11834; LANO adapter protein; LAP and no PDZ protein; Leucine rich repeat containing protein 1; Leucine-rich repeat-containing protein 1; Lrrc1; LRRC1_HUMAN.  

研究领域 :  肿瘤  细胞生物  免疫学  发育生物学  转录调节因子  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  59kDa

细胞定位 :  细胞浆 细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Lano/LRRC1:261-360/524

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The primary function of these motifs is to provide a versatile structural framework to mediate the formation of protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. LRRC1 (leucine-rich repeat-containing protein 1), also known as LANO adapter protein or LAP and no PDZ protein, is a 524 amino acid protein that contains 17 LRR repeats. Localized to the cytoplasm and the membrane, LRRC1 is expressed strongly in placenta and testis, with lower levels found in heart, kidney, thyroid, lung, prostate, colon and trachea. LRRC1 interacts with PSD-95 and SAP 97, and may form a complex with SAP 97 and ERBIN. LRRC1 is expressed as two isoforms produced by alternative splicing events.

Subunit:

Interacts with DLG1 and DLG4. May form a complex with DLG1 and ERBB2IP, where interaction between LRRC1 and ERBB2IP is indirect.

Subcellular Location:

Cytoplasm. Membrane. Localized at the basolateral side of epithelial cells.

Tissue Specificity:

Expressed strongly in testis and placenta, followed by heart, lung, kidney, thyroid, trachea, colon, prostate and pancreas.

Similarity:

Contains 17 LRR (leucine-rich) repeats.

SWISS:

Q9BTT6

Gene ID:

55227

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.