产品货号 :  mlR17701

英文名称 :  MOCS2

中文名称 :  钼辅因子合成蛋白2抗体

别    名 :  MCBPE; MOCO1; MOCO1 B; MOCO1B; MOCS 2; MOCS2; MOCS2A; MOCS2B; Molybdenum cofactor biosynthesis protein E; Molybdenum cofactor synthesis 2; Molybdenum cofactor synthesis protein 2 large subunit; molybdenum cofactor synthesis protein 2 small subunit; molybdenum cofactor synthesis protein 2A; Molybdenum cofactor synthesis protein 2B; Molybdopterin synthase; Molybdopterin synthase large subunit; molybdopterin-synthase small subunit; MPT synthase; MPTS; OTTHUMP00000122459; sulfur carrier protein MOCS2A.  

研究领域 :  细胞生物  信号转导  新陈代谢  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  21kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human MOCS2:51-150/188

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]

Function:

The large (MOCS2B) and small (MOCS2A) subunits of molybdopterin synthase are both encoded from the MOCS2 gene by overlapping open reading frames. MOCS2B is the catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. It acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.

Subunit:

Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

Subcellular Location:

Cytoplasmic

Tissue Specificity:

Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas.Very low levels are found in lung and peripheral blood leukocytes.

DISEASE:

Molybdenum cofactor deficiency, complementation group B(MOCODB)

Similarity:

Belongs to the MoaE family. MOCS2B subfamily.

SWISS:

O96007

Gene ID:

4338

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.