产品货号 : mlR6685
英文名称 : SCN10A/Nav1.8
中文名称 : 钠通道蛋白10α抗体
别 名 : mPN3; Peripheral nerve sodium channel 3; Pn3 (gene name)v PN3; Scn10a; Sensory neuron sodium channel; Sns (gene name); SNS; sodium channel protein type 10 subunit alpha; Sodium channel protein type X alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.8; NAV1.8.
研究领域 : 神经生物学 通道蛋白 细胞膜受体
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 215kDa
细胞定位 : 细胞膜 细胞外基质
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human SCN10A/NAV1.8:1151-1250/1956
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Nav1.8 protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Nav1.8 forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Nav1.8 plays a role in neuropathic pain mechanisms.
Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms.
Subunit:
The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L.
Subcellular Location:
Membrane; Multi-pass membrane protein. Note=It can be translocated to the extracellular membrane through association with S100A10.
Tissue Specificity:
Expressed in the dorsal root ganglia and sciatic nerve.
Post-translational modifications:
Ubiquitinated by NEDD4L; which promotes its endocytosis.
Similarity:
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
Contains 1 IQ domain.
SWISS:
Q9Y5Y9
Gene ID:
6336
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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