产品货号 :  mlR7697

英文名称 :  BS69

中文名称 :  腺病毒5结合蛋白BS69/骨形态发生蛋白受体相关分子1抗体

别  名 :  Adenovirus 5 E1A binding protein; Bone morphogenetic protein receptor associated molecule 1; BRAM1; BS69 variant 1; BS69 variant 2; BS69 variant 3; BS69 variant 4; Zinc finger MYND domain containing 11; ZMYND11.  

研究领域 :  细胞生物  细胞周期蛋白  转录调节因子  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Chicken, Dog, Horse, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  71kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Adenovirus 5 E1A binding protein:501-602/602

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function:

Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors.

Subunit:

Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Interacts (via MYND-type zinc finger) with EZH2. Interacts with E2F6.

Subcellular Location:

Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.

Tissue Specificity:

Ubiquitous.

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR.

Ubiquitinated, leading to proteasomal degradation.

Similarity:

Contains 1 bromo domain.

Contains 1 MYND-type zinc finger.

Contains 1 PHD-type zinc finger.

Contains 1 PWWP domain.

SWISS:

Q15326

Gene ID:

10771

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片