产品货号 : mlR6069
英文名称 : LLGL1/Lgl1
中文名称 : 相似肿瘤抑制基因HUGL抗体
别 名 : DLG4; Hugl 1; HUGL; Hugl-1; HUGL1; Human homolog to the D-lgl gene protein; L2GL1_HUMAN; Lethal giant larvae homolog 1 (Drosophila); Lethal giant larvae homolog 1; Lethal(2) giant larvae protein homolog 1; LLGL; Llgl1; Ly 49G2; Ly49G2; Mgl1; Mlgl.
研究领域 : 肿瘤 细胞生物 信号转导 细胞周期蛋白 细胞骨架
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Cow, Horse,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 117kDa
细胞定位细胞浆 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human LLGL1/LLGL2:801-900/1064
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍background:
LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.
Subunit:
Associated with nonmuscle myosin II heavy chain. Interacts with PRKCI/aPKC, PARD6B/Par-6 and PARD6A. Interacts with STX4A.
Subcellular Location:
Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts.
Tissue Specificity:
Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.
Similarity:
Belongs to the WD repeat L(2)GL family.
Contains 14 WD repeats.
SWISS:
Q15334
Gene ID:
3996
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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