产品货号 :  mlR51410

英文名称 :  BAIAP2/IRSp53 

中文名称 :  小鼠抗胰岛素受体底物p53蛋白单克隆抗体 

别    名 :  Insulin receptor substrate P53; IRSp53; IRS P53; IRS-P53; Baiap2; BAI1 associated protein 2 isoform 3; Brain-specific angiogenesis inhibitor 1-associated protein 2; BAI1-associated protein 2; Insulin receptor tyrosine kinase substrate protein p53; Insulin receptor substrate p53; Insulin receptor substrate protein of 53 kDa; IRSp53; BAIP2_HUMAN; BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; Fas ligand-associated factor 3; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; FLAF3; IRS-58; IRSp53/58.  

研究领域 :  细胞生物  神经生物学  细胞凋亡  细胞膜受体  糖尿病  内分泌病  

抗体来源 :  Mouse

克隆类型 :  Monoclonal

克 隆 号 :  4G7

交叉反应 :   Human, Mouse,

产品应用 :  WB=1:500-2000  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user 

分 子 量 :  61kDa

细胞定位 :  细胞浆 细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml 

免 疫 原 :  Recombinant human BAIAP2:

亚    型 :  IgG2b

纯化方法 :  affinity purified by Protein G

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed 

产品介绍 : The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the end of this gene results in three products of undetermined function.

Function:

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation.

Subunit:

Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1. Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir.

Subcellular Location:

Cell Membrane and Cytoplasmic.

Tissue Specificity:

Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. 

Post-translational modifications:

Phosphorylated on tyrosine residues by INSR in response to insulin treatment. 

Similarity:

Contains 1 IMD (IRSp53/MIM homology) domain.

Contains 1 SH3 domain. 

SWISS:

Q9UQB8

Gene ID:

10458 

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.