产品货号 :  mlR19054

英文名称 :  NCOA7

中文名称 :  核受体共激活因子7抗体

别    名 :  140 kDa estrogen receptor associated protein; 9030406N13Rik; dJ187J11.3; ERAP140; ESNA1; Estrogen nuclear receptor coactivator 1; FLJ45605; MGC88425; Nbla00052; Nbla10993; Nuclear receptor coactivator 7; RGD1566426.  

研究领域 :  细胞生物  转录调节因子  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  107kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human NCOA7:261-360/942

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  NCoA-7 is a 942 amino acid nuclear protein that enhances nuclear receptor transcriptional activities and coactivates several nuclear receptors including PPAR©, ERå, TR∫1 and RARå. Highly expressed in brain and weakly expressed in pancreas, bladder, ovary, spinal cord, prostate, mammary gland, ovary, uterus and stomach, NCoA-7 is a member of the OXR1 family and contains one LysM repeat and a TLD domain. Six NCoA-7 isoforms are known to exist due to alternative splicing events, and the gene encoding NCoA-7 maps to human chromosome 6q22.31 and mouse chromosome 10 A4.

Function:

Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.

Subunit:

Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.

Subcellular Location:

Nucleus

Tissue Specificity:

Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.

Similarity:

Belongs to the OXR1 family.

Contains 1 LysM repeat.

Contains 1 TLD domain.

SWISS:

Q8NI08

Gene ID:

135112

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.