产品货号 :  mlR1894

英文名称 :  GRM4

中文名称 :  促代谢型谷氨酸受体4抗体

别    名 :  G protein coupled receptor family C group 1 member D; G protein coupled receptor GRM 4; G protein coupled receptor GRM4; Glutamate receptor metabotropic 4; GPRC 1D; GPRC1D; GRM 4; GRM4; GRM4_HUMAN; Metabotropic glutamate receptor 4; mGlu 4; mGlu R4; mGlu4; mGluR 4; mGluR4.  

研究领域 :  免疫学  神经生物学  细胞凋亡  G蛋白偶联受体  G蛋白信号  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Pig, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  102kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human GRM4:301-400/912 <Extracellular>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍  :  L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Function:

Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Subunit:

Interacts with PICK1

Subcellular Location:

Cell membrane.

Tissue Specificity:

Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.

Similarity:

Belongs to the G-protein coupled receptor 3 family.

SWISS:

Q14833

Gene ID:

2914

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.