产品货号 :  mlR1473

英文名称 :  AKAP95

中文名称 :  蛋白激酶A锚定蛋白95抗体

别    名 :  AKAP8; AKAP-8; AKAP-95; A-kinase Anchoring Protein 95; CCK 1; CCK1; CCL 28; Chemokine (C-C motif) ligand 28; MEC; Mucosae associated epithelial chemokine; SCYA28; Small inducible cytokine A28; AKP8L_HUMAN.  

研究领域 :  细胞生物  信号转导  细胞凋亡  细胞周期蛋白  激酶和磷酸酶  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  71kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human AKAP95:401-550/646

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

Function:

Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.

Subunit:

Interacts with PRPF40A. Binds to the C-terminal of RNA helicase A and to TMPO-beta. Interacts with RNF43.

Subcellular Location:

Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix. Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear matrix.

Tissue Specificity:

Expressed in the brain cortex (at protein level).

Post-translational modifications:

Phosphorylated on serine or threonine residues possibly by PKA.

Similarity:

Belongs to the AKAP95 family.

Contains 2 C2H2 AKAP95-type zinc fingers.

SWISS:

O43823

Gene ID:

10270

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信号传导（Signaling Intermediates）

蛋白激酶A锚定蛋白95参与细胞分裂染色体集缩的建立和集缩状态的保持,参与基因表达调控、DNA复制以及维持mRNA的稳定,参与胚胎发育、细胞凋亡及细胞周期调控等。