产品货号 :  mlR0656

英文名称 :  MRP3

中文名称 :  多药耐药相关蛋白3抗体

别    名 :  ABC 31; ABC31; ABCC 3; ABCC3; ATP binding cassette sub family C (CFTR/MRP) member 3; ATP binding cassette sub family C; ATP binding cassette sub family C member 3; Canalicular multispecific organic anion transporter 2; Canicular multispecific organic anion transporter; CMOAT 2; CMOAT2; EST90757; MLP 2; MLP2; MOAT D; MOATD; MRP 3; Multi specific organic anion transporter D; Multidrug resistance associated protein 3; Multidrug resistance associated protein; Multispecific organic anion tranporter D.  

研究领 :  域肿瘤  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Human, Mouse, Rat,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  190kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human MRP3:1201-1300/1527 <Cytoplasmic>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   MRP3 (Canalicular Multi Organic Anion Transporter 2 / Multidrug Resistance Associated Protein 3, cMOAT2) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The specific function of MRP3 has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions.

Function:

May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.

Subcellular Location:

Membrane; Multi-pass membrane protein.

Tissue Specificity:

Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.

Similarity:

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

SWISS:

O15438

Gene ID:

8714

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.