产品货号 :  mlR19606

英文名称 :  SDS3

中文名称 :  缺陷沉默抑制因子3抗体

别    名 :  2400003N08Rik; 2410008L21Rik; 45 kDa Sin3 associated polypeptide; 45 kDa Sin3-associated polypeptide; AU067672; FLJ00052; FLJ13739; MGC104711; mSds3; RGD1305986; SAP45; SDS3; SDS3, yeast, homolog of; SDS3_HUMAN; Sin3 histone deacetylase corepressor complex component SDS3; Sin3A associated protein 45kDa; Suds3; Suppressor of defective silencing 3; Suppressor of defective silencing 3 homolog (S cerevisiae); Suppressor of defective silencing 3 homolog (SDS3 S cerevisiae); Suppressor of defective silencing 3 protein homolog.  

研究领域 :  转录调节因子  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Cow, Monkey,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  38kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human SDS3:251-328/328

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]

Function:

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Tissue Specificity:

Expressed in various cancer cell ines.

Similarity:

Belongs to the SDS3 family.

SWISS:

Q9H7L9

Gene ID:

64426

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.