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您当前的位置:首页 > 抗体 > 核酸内切酶III样蛋白1抗体

核酸内切酶III样蛋白1抗体

  • 产品货号:mlR19497-1 收藏此商品
  • 销售价:1580.00-2480.00
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产品 :  mlR19497

英文名称 :  NTH1

中文名称 :  核酸内切酶III样蛋白1抗体

    :  Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; Endonuclease III like protein 1; Endonuclease III-like protein 1; hNTH1; NTH 1; nth endonuclease III like 1 (E. coli); NTH endonuclease III Like 1; NTH1; NTHL 1; Nthl1; NTH_HUMAN; OCTS 3; OCTS3.  

研究领域 :  细胞生物  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

:  31kDa

细胞定位 :  细胞核

    :  Lyophilized or Liquid

    :  1mg/ml

:  KLH conjugated synthetic peptide derived from human NTH1:101-200/312

    :  IgG

纯化方法 :  affinity purified by Protein A

:  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]

Function:

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Subcellular Location:

Nucleus.

Tissue Specificity:

Widely expressed with highest levels in heart and lowest levels in lung and liver.

Similarity:

Belongs to the Nth/MutY family.

SWISS:

P78549

Gene ID:

4913

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

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