产品货号 :  mlR21041

英文名称 :  POMZP3

中文名称 :  POMZP3蛋白抗体

别    名 :  MGC8359; OTTHUMP00000208707; OTTHUMP00000208708; POM (POM121 homolog rat) and ZP3 fusion; POM (POM121 rat homolog) and ZP3 fusion; POM 121; POM and ZP3 fusion; POM ZP3; POM ZP3 fusion protein; POM-ZP3; POM121 and ZP3 fusion protein; POM121; POM121/ZP3 fusion protein; POMZP 3; POMZP3; POMZP3 fusion protein; POZP3_HUMAN.  

研究领域 :  细胞生物  免疫学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  21kDa

细胞定位 :  分泌型蛋白

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human POMZP3:121-187/187

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Function:

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Subcellular Location:

Secreted > extracellular space > extracellular matrix and Cell membrane.

Tissue Specificity:

Expressed in spleen, thymus, pancreas, testis, ovary, small intestine, colon and lymphocytes.

Post-translational modifications:

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.

N-glycosylated.

O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.

SWISS:

Q6PJE2

Gene ID:

22932

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.