产品货号 :  mlR6392

英文名称 :  PCNP

中文名称 :  PEST含核蛋白抗体

别  名 :  PCNP; PCNP_HUMAN; PEST containing nuclear protein; PEST proteolytic signal containing nuclear protein; PEST proteolytic signal-containing nuclear protein; PEST-containing nuclear protein.  

研究领域 :  细胞生物  染色质和核信号  细胞周期蛋白  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  19kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PCNP:21-120/178

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   PCNP is a novel 178 amino acid nuclear protein implied to play a role in cell cycle regulation and tumorigenesis. PCNP is ubiquitinated post-translationally by NIRF (Np95/ICBP90-like RING finger protein), a ubiquitin ligase. Existing as three isoforms produced by alternative splicing events, PCNP is encoded by a gene mapping to human chromosome 3q12.3. Chromosome 3 houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3

Function:

May be involved in cell cycle regulation.

Subunit:

Interacts with UHRF2/NIRF.

Post-translational modifications:

Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.

SWISS:

Q8WW12

Gene ID:

57092

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.