产品货号 :  mlR19240

英文名称 :  CHRNA5

中文名称 :  烟碱型乙酰胆碱受体α5抗体

别    名 :  Acetylcholine receptor nicotinic alpha 5 (neuronal); ACHA5_HUMAN; Cholinergic receptor neuronal nicotinic alpha polypeptide 5; Cholinergic receptor nicotinic alpha 5; Cholinergic receptor nicotinic alpha polypeptide 5; CHRNA 5; CHRNA5; LNCR2; NACHRA 5; NACHRA5; Neuronal acetylcholine receptor subunit alpha 5; Neuronal acetylcholine receptor subunit alpha-5; Neuronal nicotinic acetylcholine receptor alpha 5 subunit; Neuronal nicotinic acetylcholine receptor, alpha5 subunit; OTTHUMP00000185019.  

研究领域 :  免疫学  神经生物学  细胞膜受体  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  51kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human CHRNA5:151-250/468 <Extracellular>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction > synapse > postsynaptic cell membrane. Cell membrane.

Tissue Specificity:

High expression level is found in brain, testis, liver and kidney. Weak expression in spleen, leukocytes, small intestine and colon

Similarity:

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily 

SWISS:

P30532

Gene ID:

1138

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.