产品货号 :  mlR10783

英文名称 :  PERP/p53 apoptosis effector related to PMP22

中文名称 :  p53凋亡相关作用蛋白PMP22抗体

别    名 :  KCP 1; KCP-1; KCP1; Keratinocyte associated protein 1; Keratinocyte-associated protein 1; Keratinocytes associated protein 1; KRTCAP 1; KRTCAP1; p53 apoptosis effector related to PMP 22; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to PMP22; P53 induced protein PIGPC1; P53-induced protein PIGPC1; Perp; PERP TP53 apoptosis effector; PERP_HUMAN; PIGPC 1; PIGPC1; THW antibody TP53 apoptosis effector; Transmembrane protein THW.  

研究领域 :  细胞生物  信号转导  细胞凋亡  细胞骨架  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  21kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human p53 apoptosis effector related to PMP22:101-193/193

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   PERP (PERP, TP53 Apoptosis Effector) is a Protein Coding gene. Diseases associated with PERP include Arrhythmogenic Right Ventricular Cardiomyopathy and Uveal Melanoma. Among its related pathways are Keratinization and p53 Pathway (RnD). An important paralog of this gene is TMEM47.

Function:

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.

Subcellular Location:

Cell junction, desmosome. Cell membrane; Multi-pass membrane protein. Note=Associated with desmosomes.

Tissue Specificity:

Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.

Similarity:

Belongs to the TMEM47 family.

SWISS:

Q96FX8

Gene ID:

64065

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.