产品货号 :  mlR9900

英文名称 :  PAFAH1B2

中文名称 :  血小板衍化生长因子β抗体

别   名 :  PA1B2_HUMAN; PAF acetylhydrolase 30 kDa subunit; PAF AH 30 kDa subunit; PAF AH beta subunit; PAF AH subunit beta; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH 30 kDa subunit; PAFAH beta subunit; PAFAH subunit beta; Pafah1b2; PAFAH1B2 protein; PAFAHB; Platelet activating factor acetylhydrolase IB beta subunit; Platelet activating factor acetylhydrolase IB subunit beta; Platelet activating factor acetylhydrolase isoform Ib beta subunit; Platelet-activating factor acetylhydrolase IB subunit beta.  

研究领域 :  肿瘤  心血管  信号转导  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Horse, Sheep,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  25kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PAFAH1B2:101-200/229

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   PAFAH1B2, also known as PAFAHB, is a 229 amino acid cytoplasmic protein that belongs to the GDSL lipolytic enzyme family and the platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily. A ubiquitously expressed catalytic subunit of the cytosolic PAFAH1B heterotrimeric complex, PAFAH1B2 inactivates PAF by removing the acetyl group at the sn-2 position. Along with the beta subunit, PAFAH1B is made up of alpha and gamma subunits. The gene that encodes PAFAH1B2 consists of approximately 32,628 bases and maps to human chromosome 11q23.3. Chromosome 11 houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that map to chromosome 11.

Function:

Inactivates PAF by removing the acetyl group at the sn-2position. This is a catalytic subunit.

Subunit:

Cytosolic PAF-AH IB is formed of three subunits of 45 kDa(alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activityof the enzyme resides in the beta and gamma subunits, whereas thealpha subunit has regulatory activity. Trimer formation is notessential for the catalytic activity.

Subcellular Location:

Cytoplasm.

Tissue Specificity:

Ubiquitous.

Similarity:

Belongs to the 'GDSL' lipolytic enzyme family.Platelet-activating factor acetylhydrolase IB beta/gamma subunitssubfamily.

SWISS:

P68402

Gene ID:

5049

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片