产品货号 :  mlR16781

英文名称 :  KLRC3

中文名称 :  杀伤细胞凝集素样受体C亚家族成员3抗体

别    名 :  Killer cell lectin like receptor subfamily C member 3; KLRC 3; KLRC3; NK cell receptor E; NKG2 E activating NK receptor; NKG2 E; NKG2 E type II integral membrane protein; NKG2-E type II integral membrane protein; NKG2-E-activating NK receptor; NKG2E activating NK receptor; NKG2E; NKG2E type II integral membrane protein; NKG2E_HUMAN.  

研究领域 :  细胞生物  免疫学  细胞膜受体  淋巴细胞  t-淋巴细胞  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  27kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human KLRC3:51-150/240

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍background:

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function:

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Subcellular Location:

Membrane.

Tissue Specificity:

Natural killer cells.

Similarity:

Contains 1 C-type lectin domain.

SWISS:

Q07444

Gene ID:

3823

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.