产品货号 :  mlR0447

英文名称 :  Thyroid peroxidase

中文名称 :  甲状腺过氧化物酶抗体

别    名 :  MSA; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX.  

研究领域 :  肿瘤  细胞生物  免疫学  神经生物学  信号转导  生长因子和激素  激酶和磷酸酶  内分泌病  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Human, Mouse, Rat,

产品应用 :  WB=1:500-2000  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  101kDa

细胞定位 :  细胞膜 细胞外基质

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from rat Thyroid peroxidase:351-450/914 <Extracellular>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].

Function:

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Subunit:

Interacts with DUOX1, DUOX2 and CYBA.

Subcellular Location:

Membrane; Single-pass type I membrane protein.

Isoform 3: Cell surface.

Post-translational modifications:

Glycosylated.

Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.

Cleaved in its N-terminal part.

DISEASE:

Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.

Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]. A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.

Similarity:

Belongs to the peroxidase family. XPO subfamily.

Contains 1 EGF-like domain.

Contains 1 Sushi (CCP/SCR) domain.

SWISS:

P35419

Gene ID:

7173

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.