产品货号 :  mlR0652

英文名称 :  Connexin-45

中文名称 :  间隙连接蛋白45抗体

别    名 :  Connexin 45; Connexin45; Connexin-45; CX 31.9; CX 45; CX31.9; CX45; DKFZp686P0738; Gap junction alpha 7 protein; Gap junction alpha-7 protein; Gap junction protein alpha 7 45kDa; Gap junction protein alpha 7; Gap junction protein, gamma 1, 45kDa; GJA 7; GJA7; GJD3; Gap junction gamma-1 protein; CXG1_HUMAN.  

研究领域 :  心血管  信号转导  细胞粘附分子  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Dog, Pig,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  45kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Connexin-45:81-130/396

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.

Function:

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins.

Subunit:

A connexon is composed of a hexamer of connexins. Interacts with CNST.

Subcellular Location:

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Similarity:

Belongs to the connexin family. Gamma-type subfamily.

SWISS:

P36383

Gene ID:

10052

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

通道蛋白（Channel Protein）

Connexin45又称缝隙连接膜通道蛋白alpha7，Cx45构成细胞间的通道,小分子成份可以借此在细胞间扩散。

Connexin-45是心肌缝隙连接蛋白的主要蛋白之一。