产品货号 :  mlR19095

英文名称 :  NECAP1

中文名称 :  NECAP1蛋白抗体

别    名 :  Adaptin ear binding coat associated protein 1; Adaptin ear-binding coat-associated protein 1; DKFZP566B183; MGC131900; NECAP 1; NECAP endocytosis associated 1; NECAP endocytosis-associated protein 1; NECAP-1; NECAP1; NECP1_HUMAN.  

研究领域 :  细胞生物  神经生物学  信号转导  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Cow,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  30kDa

细胞定位 :  细胞浆 细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human NECAP1:1-100/275

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  NECAP 1 is a 275 amino acid cell membrane protein belonging to the NECAP family that localizes to the clathrin-coated vesicle membrane. NECAP 1 is encoded by a gene that maps to human chromosome 12p13.31 and contains two WXXF motifs that are used to mediate binding of accessory proteins to ear domains of various proteins such as AP-1, AP-2 and GGAs. Expressed primarily in brain and existing as two alternatively spliced isoforms, NECAP 1 colocalizes with AP-2 at the plasma membrane by binding AP-2s alpha-ear domain.

Function:

Involved in endocytosis.

Subcellular Location:

Cytoplasmic vesicle > clathrin-coated vesicle membrane. Cell membrane. Colocalizes with AP-2 at the plasma membrane.

Similarity:

Belongs to the NECAP family.

SWISS:

Q8NC96

Gene ID:

25977

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.