产品货号 :  mlR17165

英文名称 :  TPGS1

中文名称 :  电压门控离子通道蛋白TPGS1抗体

别    名 :  C19orf20; two pore segment channel 1; Gene trap ROSA b geo 22; GTRGEO22; PGs1; Tubulin polyglutamylase complex subunit 1.  

研究领域 :  细胞生物  信号转导  通道蛋白  新陈代谢  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  31kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human TPGS1:21-120/290

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 TPCN1 is a widely expressed, 816 amino acid voltage-gated cation channel protein with predominant expression in lung, liver, heart and kidney. In the kidney, TPCN1 localizes to the inner medullary collecting ducts. In contrast with the distantly related four-domain voltage-gated calcium and sodium channels and the more closely related four-domain ion transport protein located on the surface of sperm cells (CatSper), TPCN1 is a two-domain channel. Similar to the four-domain channel structure, each of the two homologous domains that comprise TPCN1 contains six transmembrane segments (S1-S6) with a pore loop between S5 and S6 and a voltage sensor segment that is positively charged. TPCN1 has hydrophilic N- and C-termini that localize to the cytoplasm.

Function:

TPGS1 may act in the targeting of the tubulin polyglutamylase complex. It is required for the development of the spermatid flagellum.

Subunit:

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

Subcellular Location:

Microtubule.

SWISS:

Q6ZTW0

Gene ID:

91978

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.