产品货号 :  mlR19216

英文名称 :  NBEAL1

中文名称 :  NBEAL1蛋白抗体

别    名 :  neurobeachin-like 1; A530083I02Rik; ALS2CR16; ALS2CR17; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 16; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 17; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein; Beach; FLJ26555; MGC164581; MGC168834; NBEAL 1; NBEAL1; Neurobeachin like protein 1; OTTHUMP00000205117.  

研究领域 :  肿瘤  细胞生物  免疫学  神经生物学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  307 , 151kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human NBEAL1:1251-1350/2694

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed :  PubMed

产品介绍 :  NBEAL1 is a 2,694 amino acid protein that belongs to the WD repeat Neurobeachin family. While highly expressed in kidney, brain, prostate and testis, NBEAL1 is also found at low levels in peripheral blood leukocytes, small intestine, ovary and colon. NBEAL1 contains one BEACH domain and two WD repeats, and undergoes alternative splicing to produce two isoforms. The gene encoding NBEAL1 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.

Function:

Neurobeachin-like 1 belongs to the WD repeat neurobeachin family. It contains 1 BEACH domain and 2 WD repeats. Neurobeachin-like 1 is highly expressed in brain, kidney, prostate and testis and weakly expressed in ovary, small intestine, colon and peripheral blood leukocytes. It may be correlative to several tumors, such as ovary serous adenocarcinoma and metastasis mammary gland carcinoma breast.

Tissue Specificity:

Highly expressed in brain, kidney, prostate and testis. Weakly expressed in ovary, small intestine, colon and peripheral blood leukocytes. May be correlative to several tumors, such as ovary serous adenocarcinoma and metastasis mammary gland carcinoma breast.

Similarity:

Belongs to the WD repeat neurobeachin family.

Contains 1 BEACH domain.

Contains 1 BEACH-type PH domain.

Contains 2 WD repeats.

SWISS:

Q6ZS30

Gene ID:

65065

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.