产品货号 :  mlR19025

英文名称 :  NAS6

中文名称 :  NAS6蛋白抗体

别    名 :  Nas6p; ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6; Probable 26S proteasome regulatory subunit p28; Proteasome interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); Proteasome non ATPase subunit 6.  

研究领域 :  细胞生物  泛素  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Saccharomyces cerevisiae

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  26kDa

细胞定位 :  细胞核 细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human NAS6:41-140/228

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   NAS6 (p28) is a proteasome-interacting protein which acts as a chaperone to assemble the base sub-complex of the 19S RP which is involved in the ATP-dependent degradation of ubiquitinated proteins. NAS6 is composed of 226 amino acid residues with calculated molecular masses of 24.4kD.

Function:

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the 19S regulatory complex (RC) and appears to have an overlapping role with RPN14.

Subunit:

Interacts with RPT3.

Subcellular Location:

Cytosol; Nucleus; Proteasome complex

Similarity:

Contains 6 ANK repeats.

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.