产品货号 :  mlR11443

英文名称 :  NMS

中文名称 :  神经调节肽S抗体

别    名 :  Neuromedin S; Neuromedin-S; NeuromedinS; Nms; NMS_HUMAN; Prepro NMS.   

研究领域 :  肿瘤  心血管  神经生物学  信号转导  生长因子和激素  新陈代谢  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  4kDa

细胞定位 :  分泌型蛋白

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Neuromedin S:81-153/153

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed :  PubMed

产品介绍  :  NMS is a 153 amino acid secreted protein that belongs to the NmU family. NMS is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. The gene that encodes NMS consists of approximately 12,799 bases and maps to human chromosome 2q11.2. Consisting of 237 million bases and encoding over 1,400 genes, chromosome 2 makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8.

Function:

NMS (neuromedin S) is a 36-amino acid neuropeptide specifically expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus. NMS shares a C-terminal core structure with NMU. NMS mRNA is highly expressed in the central nervous system, spleen and testis. NMS may be implicated in the regulation of circadian rhythms and feeding behavior.

Subcellular Location:

Secreted.

Similarity:

Belongs to the NmU family.

SWISS:

Q5H8A3

Gene ID:

129521

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片