产品货号 :  mlR19097

英文名称 :  Multimerin 2

中文名称 :  Multimerin 2蛋白抗体

别    名 :  Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; EMILIN like protein EndoGlyx 1; EMILIN-3; EMILIN3; ENDOGLYX 1; EndoGlyx-1; EndoGlyx-1 p125/p140 subunit; ENDOGLYX1; MMRN2; MMRN2_HUMAN; Multimerin-2.  

研究领域 :  细胞生物  细胞膜蛋白  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Horse,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  102kDa

细胞定位 :  分泌型蛋白

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Multimerin 2:361-460/949

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

Function:

Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

Subcellular Location:

Secreted > extracellular space > extracellular matrix.

Tissue Specificity:

Endothelium.

Post-translational modifications:

N- and O-glycosylated.

Similarity:

Contains 1 C1q domain.

Contains 1 EMI domain.

SWISS:

Q9H8L6

Gene ID:

79812

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.