产品货号 :  mlR12584

英文名称 :  PDE6A

中文名称 :  磷酸二酯酶6α抗体

别    名 :  PDE6 alpha; 5''-cyclic phosphodiesterase subunit alpha; CGPR A; GMP PDE alpha; GMP-PDE alpha; PDE 6 alpha; PDE 6A; PDE V B1; PDE V-B1; PDE6A; PDE6A_HUMAN; PDEA; Phosphodiesterase 6 alpha; Phosphodiesterase 6A alpha subunit; Phosphodiesterase 6A cGMP specific rod alpha; Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha; Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit; Rod cGMP-specific 3''.  

研究领域 :  细胞生物  神经生物学  信号转导  细胞膜蛋白  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  99kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PDE6A:101-200/860

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Function:

This protein participates in processes of transmission and amplification of the visual signal.

Subcellular Location:

Cell membrane.

DISEASE:

Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Similarity:

Belongs to the cyclic nucleotide phosphodiesterase family.

Contains 2 GAF domains.

SWISS:

P16499

Gene ID:

5145

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.