产品货号 :  mlR17761

英文名称 :  MRGPRX4

中文名称 :  MRGPRX4蛋白抗体

别    名 :  G protein coupled receptor MRGX4; G protein coupled receptor SNSR5; G protein coupled receptor SNSR6; GPCR; Mas related G protein coupled receptor member X4; Mas related G protein coupled-receptor family, member X4; MAS related GPR, member X4; Mas-related G-protein coupled receptor member X4; MGC129753; MGC129754; MRGPRX4; MRGX4; MRGX4_HUMAN; Sensory neuron specific G protein coupled receptor 5/6; Sensory neuron-specific G-protein coupled receptor 5/6; SNSR5; SNSR6.  

研究领域 :  细胞生物  G蛋白偶联受体  G蛋白信号  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  36kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human MRGPRX4:251-322/322 <Cytoplasmic>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed :  PubMed

产品介绍 :  Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the function of nociceptive neurons. This integral membrane protein may also regulate nociceptor development and/or the sensation or modulation of pain. There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G?q- and G?i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G?q-regulated pathways. G?q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons.

Function:

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins.

Subcellular Location:

Cell membrane.

Tissue Specificity:

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Similarity:

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

SWISS:

Q96LA9

Gene ID:

117196

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.