产品货号 :  mlR17743

英文名称 :  MPV17L

中文名称 :  MPV17L蛋白抗体

别    名 :  FLJ39599; M LP homolog; M LPH; MGC70356; MLPH1; MLPH2; MPV 17L; Mpv17 like protein type 1; Mpv17 like protein type 2; MPV17 mitochondrial membrane protein like; MPV17L1.  

研究领域 :  细胞生物  免疫学  细胞凋亡  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  22kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human MPV17L:101-160/196

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   MPV17L is a 196 amino acid multi-pass membrane protein belonging to the peroxisomal membrane protein PXMP2/4 family. M-LPS (also known as M-LPH1) and M-LPL (also known as M-LPH2) are alternatively spliced isoforms of MPV17L and are ubiquitously expressed in human tissues, however only M-LPS exists at the protein level and mainly resides in kidney. MPV17L may be involved in protecting against mitochondrial oxidative stress and apoptosis, and participates in reactive oxygen species (ROS) metabolism by up- or down-regulating genes of antioxidant enzymes. MPV17L may play a role in the development of early-onset glomerulosclerosis, which is the hardening or formation of scar tissue of the glomerulus in the kidney. The gene encoding MPV17L maps to human chromosome 16p13.11.

Function:

MPV17L Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes.

Subcellular Location:

Isoform 1: Peroxisome membrane; Multi-pass membrane protein.

Tissue Specificity:

Isoform 1 is detected in the kidney (at protein level). Isoform 1 and isoform 2 are expressed in the kidney, heart, liver, lung, pancreas and skeletal muscle.

Similarity:

Belongs to the peroxisomal membrane protein PXMP2/4 family.

SWISS:

Q2QL34

Gene ID:

255027

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.