产品货号 :  mlR10940

英文名称 :  phospho-Ephrin B2 (Tyr311/316)

中文名称 :  磷酸化Ephrin B2抗体

别    名 :  phospho-Ephrin B2 (Tyr311+Tyr316); Ephrin B2 (phospho Y311 + Y316); CEK5 ligand; EFNB1; ELK L; EphrinB; Ephrin-B; ELK ligand; ELKL; EPH related receptor tyrosine kinase ligand 2; Ephrin B Precursor; Ephrin B1; Ephrin B2; LERK 2; LERK2; EFNB1_HUMAN; EFNB2_HUMAN.  

研究领域 :  肿瘤  细胞生物  免疫学  神经生物学  信号转导  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  36kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated Synthesised phosphopeptide derived from human Ephrin B2 around the phosphorylation site of Tyr311/316:GD(p-Y)GHPV(p-Y)IV

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase.

Subunit:

Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein.

Subcellular Location:

Membrane; single pass type I membrane protein.

Tissue Specificity:

Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.

Similarity:

Belongs to the ephrin family.

Contains 1 ephrin RBD (ephrin receptor-binding) domain.

SWISS:

P52799

Gene ID:

1947

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.