产品货号 :  mlR17342

英文名称 :  hnRNP A/B

中文名称 :  异质核核糖核蛋白A/B抗体

别    名 :  ABBP 1; ABBP-1; ABBP1; APOBEC1 binding protein 1; APOBEC1-binding protein 1; Apolipoprotein B mRNA editing enzyme catalytic polypeptide 1- protein 1; FLJ40338; Heterogeneous nuclear ribonucleoprotein A/B; hnRNP A/B; hnRNP type A/B protein; HNRNPAB; hnRNP B HNRPAB; ROAA_HUMAN.  

研究领域 :  细胞生物  结合蛋白  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Pig, Cow, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  36kDa

细胞定位 :  细胞核 细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human hnRNP A/B:1-100/332

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C 

PubMed :  PubMed

产品介绍 :  This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Function:

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Subcellular Location:

Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Tissue Specificity:

Ubiquitous.

Post-translational modifications:

Dimethylation at Arg-322 is probably asymmetric.

Similarity:

Contains 2 RRM (RNA recognition motif) domains. 

SWISS:

Q99729

Gene ID:

3182

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.