产品货号 :  mlR18723

英文名称 :  MCF2L2

中文名称 :  MCF2变换序列样蛋白2抗体

别    名 :  ARHGEF22; Dbs related Rho family guanine nucleotide exchange factor; Dbs-related Rho family guanine nucleotide exchange factor; DKFZp686K0690; DRG; FLJ42509; KIAA0861; MCF.2 cell line derived transforming sequence like 2; MCF2 transforming sequence like protein 2; MCF2-transforming sequence-like protein 2; MCF2L2; MF2L2_HUMAN; Probable guanine nucleotide exchange factor MCF2L2; Rho family guanine nucleotide exchange factor.  

研究领域 :  肿瘤  细胞生物  神经生物学  信号转导  G蛋白信号  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  127kDa

细胞定位 :  细胞核 细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human MCF2L2:741-840/1114

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   MCF2L2 is a 1,114 amino acid protein that contains one spectrin repeat, one PH domain, one DH domain and one CRAL-TRIO domain. Expressed at high levels in brain and also present in testis and pancreas, MCF2L2 is thought to function as a GEF, catalyzing the activation of target GTPases. Variations in the gene encoding MCF2L2 may be associated with an increased susceptibility to type 2 diabetes. Multiple isoforms of MCF2L2 exist due to alternative splicing events.

Function:

Probably functions as a guanine nucleotide exchange factor.

Tissue Specificity:

Significantly expressed in brain and modestly in pancreas, brain and testis.

DISEASE:

Genetic variation in MCF2L2 may be associated with susceptibility to noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2.

Similarity:

Belongs to the MCF2 family.

Contains 1 CRAL-TRIO domain.

Contains 1 DH (DBL-homology) domain.

Contains 1 PH domain.

Contains 1 spectrin repeat.

SWISS:

Q86YR7

Gene ID:

23101

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.