产品货号 :  mlR18780

英文名称 :  MEKK1

中文名称 :  MAPK/ERK激酶1抗体

别    名 :  M3K1_HUMAN; Map3k1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK 1; Mekk; MEKK1; Mitogen activated protein kinase kinase kinase 1; Mitogen activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Mitogen-activated protein kinase kinase kinase 1; SRXY6.  

研究领域 :  肿瘤  细胞生物  信号转导  激酶和磷酸酶  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  164kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human MEKK1:401-500/1512

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Function:

Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Post-translational modifications:

Autophosphorylated.

Similarity:

Belongs to the protein kinase superfamily.

STE Ser/Thr protein kinase family.

MAP kinase kinase kinase subfamily.

Contains 1 protein kinase domain.

Contains 1 RING-type zinc finger.

Contains 1 SWIM-type zinc finger.

SWISS:

Q13233

Gene ID:

600982

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.