产品货号 :  mlR11109

英文名称 :  PCDH12

中文名称 :  原钙粘附蛋白12/血管内皮钙粘蛋白2抗体

别    名 :  PCD12_HUMAN; Pcdh12; Protocadherin 12; Protocadherin-12; Vascular cadherin 2; Vascular cadherin-2; Vascular endothelial cadherin 2; Vascular endothelial cadherin-2; VE cadherin 2; VE-cad-2; VE-cadherin-2; VECAD2.  

研究领域 :  发育生物学  神经生物学  信号转导  细胞粘附分子  细胞骨架  细胞膜蛋白  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Cow, Horse, Sheep,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg/Test  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  126kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PCDH12:401-500/1184 <Extracellular>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍  :  This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth.

Function:

Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.

Subcellular Location:

Cell membrane. Cell junction.

Tissue Specificity:

Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen.

Similarity:

Contains 6 cadherin domains.

SWISS:

Q9NPG4

Gene ID:

51294

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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