产品货号 :  mlR7693

英文名称 :  Renalase

中文名称 :  肾胺酶抗体

别    名 :  C10orf59; Chromosome 10 open reading frame 59; FLJ11218; Hypothetical protein LOC55328; MAO C; Monoamine oxidase C; RENALASE; Renalase, FAD dependent amine oxidase; RNLS antibody; RNLS_HUMAN.  

研究领域 :  心血管  神经生物学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  36kDa

细胞定位 :  分泌型蛋白

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Renalase:201-300/342

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   Renalase, a novel FAD dependent amine oxidase, is secreted by the kidney, degrades circulating catecholamines, and modulates cardiac function and lowers systemic blood pressure. In vivo, it has been found to decrease cardiac contractility and heart rate and prevents a compensatory increase in peripheral vascular tone, possibly explaining the association between increased plasma catecholamines and heightened cardiovascular risk. The plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. The administration of renalase (or renalase mimics) may offer a new approach to the treatment of hypertension commonly found in renal disease, which is associated with a marked increase in cardiovascular disease.

Function:

Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.

Subcellular Location:

Secreted.

Tissue Specificity:

Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.

Similarity:

Belongs to the renalase family.

SWISS:

Q5VYX0

Gene ID:

55328

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肾胺酶（renalase）是肾脏产生一种新型的蛋白质，是一种依赖于黄素腺嘌呤二核苷酸的胺氧化酶,由肾脏分泌入血,通过降解儿茶酚胺调节心脏功能和血压。因肾脏疾病与心血管疾病密切相关,因此研究肾胺酶的功能越来越受到人们的关注。

产品图片