产品货号 :  mlR17157

英文名称 :  Tropomodulin 4

中文名称 :  原肌球蛋白调节蛋白4抗体

别    名 :  Actin capping protein; SK TMOD; Sk-Tmod; Skeletal muscle tropomodulin; SKTMOD; TMOD 4; TMOD4; Tropomodulin 4 (muscle); Tropomodulin-4. 

研究领域 :  细胞生物  信号转导  结合蛋白  细胞骨架  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  39kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Tropomodulin 4:21-120/345

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments (1,2). A component of the membrane skeleton, TMOD binds to the amino terminus of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments (3,4). Four TMOD isoforms, TMOD1 - TMOD4, have been characterized in humans (2). TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively (5). TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1 (1). The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351 amino acid protein (1,5). The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B (5).

Function:

Tropomodulin 4 prevents the elongation and depolymerization of the actin filaments at the pointed end, and intervenes in the formation of the short actin protofilament, which determines the structure of the membrane skeleton.

Subunit:

Binds to the N-terminus of tropomyosin and to actin.

Subcellular Location:

Cytoplasm, cytoskeleton.

Tissue Specificity:

Highly expressed in skeletal muscle.

Similarity:

Belongs to the tropomodulin family.

SWISS:

Q9NZQ9

Gene ID:

29765

Important Note:

This prod