产品货号 :  mlR9710

英文名称 :  NOP2

中文名称 :  增殖相关核仁抗原抗体

别    名 :  Proliferation Associated Nucleolar Antigen: NOL 1; NUCLEOLAR ANTIGEN p120; NOP2_HUMAN.  

研究领域 :  肿瘤  细胞生物  信号转导  细胞凋亡  细胞周期蛋白  细胞分化  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  89kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human NOL1:1-100/812

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   Proliferation-associated nucleolar antigen is expressed in mid G1 phase with peak level during the S phase and a rapid degradation during late mitosis. Its expression in breast carcinoma is correlated with patient prognosis.

Function:

May play a role in the regulation of the cell cycle andthe increased nucleolar activity that is associated with the cellproliferation. May act as ribosomal RNA methyltransferase.

Subunit:

Interaction with MCRS1.

Subcellular Location:

Nuclear

Similarity:

Belongs to the methyltransferase superfamily. RsmB/NOPfamily.

SWISS:

P46087

Gene ID:

4839

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片