产品货号 :  mlR14433

英文名称 :  DSU

中文名称 :  视杆细胞相关蛋白MREG抗体

别    名 :  Dilute suppressor; Dilute suppressor protein homolog; DSU; FLJ10116; MREG_HUMAN; Melanoregulin; MGC90296; MREG; OTTHUMP00000206794; OTTHUMP00000206795; OTTHUMP00000206796; WDT 2; WDT2; Whn dependent transcript 2.  

研究领域 :  细胞生物  免疫学  神经生物学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Dog, Pig, Cow, Horse,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  25kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human DSU:101-200/214

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   The photoreceptor rod cell that is responsible for vision under conditions of low light consists of stacked arrays of disk membranes that make up its outer segment portion. Regulated by complex biochemical mechanisms, the rod outer segment is under constant renewal as new disks form at the base. MREG (melanoregulin), also known as DSU (dilute suppressor protein homolog) or WDT2, is thought to play a role in membrane fusion and in regulating the biogenesis of disk membranes of photoreceptor rods. MREG interacts with RDS (also known as Peripherin-2), a photoreceptor specific tetraspanin protein that is required to maintain normal cell structure during the renewal process of membrane fusion. MREG is 214 amino acids in length, is expressed in photoreceptor cells and and is expressed as two isoforms due to alternative splicing.

Function:

DSU (Dilute suppressor) is also known as Melanoregulin. It has a role in the incorporation of pigments into hair. It is involved in organelle biogenesis and may function in membrane fusion. It may also regulate the biogenesis of disk membranes, specialized organelles of photoreceptor rod cells.

Subcellular Location:

Apical cell membrane; Peripheral membrane protein. Note: Localizes to the inner segment and basal outer segment of rods in the retina.

Tissue Specificity:

Expressed in photoreceptor cells (at protein level).

Similarity:

Belongs to the melanoregulin family.

SWISS:

Q8N565

Gene ID:

55686

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片